Intravenous Immunoglobulin (IVIg)

Intravenous Immunoglobulin (IVIg) is a treatment made from donated plasma. It is used to quickly raise platelet counts by blocking the immune system from destroying platelets. IVIg works fast, which makes it especially useful when bleeding is present or when treatment is needed urgently.

When IVIg is used

IVIg is commonly used when:

  • A rapid rise in platelets is needed
  • There is significant bruising or bleeding
  • Steroids are not suitable or not tolerated
  • Treatment is needed before surgery or dental procedures
  • Treatment is needed during pregnancy
  • A child has moderate bleeding or needs a quick platelet increase

IVIg may be used alone or combined with corticosteroids for a stronger or faster response.

How IVIg works

IVIg works by:

  • Blocking the immune system from destroying antibody coated platelets
  • Saturating immune receptors in the spleen and liver so platelets survive longer
  • Temporarily reducing inflammation and immune activity

This allows platelet counts to rise quickly — often within 24–48 hours.

What to expect

  • IVIg is given through a drip (IV infusion) in hospital or a day treatment unit
  • Infusions may take 2–6 hours, depending on the dose and how well it is tolerated
  • Platelet counts often rise within 1–2 days
  • The effect is temporary, usually lasting days to weeks
  • Some people may need repeat doses
  • IVIg can be combined with steroids for a faster or stronger response

Your doctor will monitor your platelet count and symptoms to decide whether further treatment is needed.

Side effects

Most side effects are mild and improve after the infusion.

Common effects include:

  • Headache (very common)
  • Fatigue
  • Flu like symptoms
  • Nausea
  • Mild fever or chills

Less common effects include:

  • Migraine like headaches
  • Blood pressure changes
  • Allergic reactions
  • Aseptic meningitis (rare but more common in younger patients)

Staying well hydrated before and after the infusion can help reduce headaches.

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Adults, Children and in Pregnancy

Adults
  • IVIg is often used when a fast platelet rise is needed
  • May be preferred when steroids are not tolerated
  • Some adults may experience stronger headaches or fatigue
  • IVIg is commonly used in children with moderate bleeding or when a quick response is needed
  • IVIg is commonly used in children with moderate bleeding or when a quick response is needed
  • Many children tolerate IVIg well, though headaches can occur
  • Observation (watch and wait) is still preferred for mild cases
  • IVIg is considered safe in pregnancy
  • Often used when treatment is needed to support platelet counts before birth
  • May be combined with steroids if needed

Other Considerations

  • IVIg access in Australia is managed through BloodSTAR, with specific eligibility criteria
  • IVIg access in New Zealand is managed through New Zealand Blood Service
  • People with IgA deficiency may require special formulations
  • IVIg is a blood product, but it undergoes extensive screening and purification
  • The response is temporary and is not generally a long term treatment
  • Hydration before and after the infusion can reduce side effects

Download treatment sheets

Adult IVIg
Paediatric IVIg